Seoul St. Mary’s Hospital has developed a new photo-sensitizer that enhances the therapeutic effect of pancreatic cancer.
More than 80% of patients with pancreatic cancer receive radiotherapy or chemotherapy therapy. However, this cancer has a poor prognosis because of low response rate to existing treatment methods, and it is urgent to develop a new treatment method. The team of Prof. Myunggyu Choi and Prof. Jaemyung Park of the department of gastrointestinal internal medicine at Seoul St. Mary’s Hospital has developed a new photo-sensitizer, photosensitizer-encapsulated polymeric nanoparticle (PS-pNP). As a result, it improves the ‘photo dynamic therapy(PDT)’ effect of killing cancer cells without damaging normal cells. At the heart of photo dynamic therapy is to inject a light-sensitive “photo-sensitizer”’ into the body. The photo-sensitizer is specifically targeted to and embedded in cancer cells, so that when exposed to light, it can selectively kill cancer cells. The problem is that after the injection, the cancer cells in the body need to absorb the photo-sensitizer, but the carrier of cell membrane causes the photo-sensitizer to leak out of the cell, reducing the efficiency of the treatment. “As PS-pNP has proved to be a new light-sensitive “photo-sensitizer” with high efficacy and low side effects, we are expected to use it in clinical practice in the future,” said Prof. Choi. The results of this study were published in the September issue of the Molecular Cancer Therapeutics, publications from the American Association for Cancer Research (AACR).
Writen by : admin / November 10, 2017